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Polyglutamine Disorders
There are nine polyQ disorders identified, Almost all disease-causing coding region expansions consist of CAG repeats encoding glutamine. The exception is the GCG/polyalanine repeat expansion in the gene encoding polyA-binding protein-2, which is the cause of oculopharyngeal muscular dystrophy. including; Huntington's Disease (HD), six spinocerebellar ataxias, dentatorubral pallidoluysian atrophy (DRPLA), spinal and bulbar muscular atrophy (SBMA), Spinocerebellar ataxias (SCA) types 1, 2, 6, 7, and 17, Machado–Joseph disease (MJD/SCA3), X-linked 1 (SMAX1/SBMA),